Intranuclear Inclusion Bodies I N Carcinoma of the Thyroid Gland

Many authors have written about intranuclear inclusion bodies ; their presence has usually been linked with known virus infection, and their association with tumors has been less frequently reported. Intranuclear inclusions have been described, however, by Luck6 (1) in adenocarcinoma of the frog’s kidney. Russell ( 2 ) , and Wolf and Orton (3 ) have reported inclusion bodies in nuclei of the cells of various brain tumors. Many of the spongioblastomata contained them, but none were found in the medulloblastomata. Chemical agents are also a possible factor in their causation, as Olitsky and Harford (4) have shown by producing these bodies with aluminum hydroxide and other compounds. Both intranuclear and extranuclear inclusion bodies were reported by Pappenheimer and Maechling ( 5 ) in the epithelium of the renal tubules following bismuth administration. Blackman ( 6 ) , and Finner and Calvery ( 7 ) found intranuclear bodies in the livers and kidneys of children dying of lead poisoning. In the following case, conspicuous intranuclear inclusions were present in the neoplastic cells of a thyroid carcinoma. Unfortunately, because of the limitations of the necropsy permission, no other tissues could be examined.